Effect of Levocarnitine Plus Myoinositol Versus Myoinositol Alone on Hormonal and Insulin Resistance in PCOS Women

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-40
SponsorMst.Sumyara Khatun

About this trial

The goal of this clinical trial is to learn if combination of levocarnitine and myoinositol works better than myoinositol alone on insulin resistance and hormonal parameters in subfertile women with insulin resistant polycystic ovary syndrome . It will also learn about the safety of drug levocarnitine and myoinositol. The main questions it aims to answer are:

Does combined action of levocarnitine and myoinositol improve insulin resistance and hormonal parameters in comparison to myoinositol alone in subfertile women with insulin resistant polycystic ovary syndrome ? What medical problems do participants have when taking drug levocarnitine and myoinositol? Researchers will compare the drug combination of levocarnitine and myoinositol to myoinositol alone to see if combination therapy works better?

Participants will:

Take drug levocarnitine and myoinositol or a myoinositol alone twice daily for 3 months Visit the clinic once after 3 months for checkups and tests Keep a diary of their symptoms and the number of times.

Eligibility criteria

Qualifiers

Age:18-40 years old.

Diagnosed cases of PCOS patients(both old & new cases) according to International evidence-based guideline criteria 2023

Primary or secondary subfertility.

Insulin resistance (HOMA-IR >2.6)

Disqualifiers

Hypothyroidism

Diabetes mellitus

Hormonal (Myo-inositol,D-chiro-inositol) or insulin sensitizing drugs like Metformin,Pioglitazone etc. treatment in the last three months

Known hypersensitivity to Myo-inositol and Levo-carnitine

Trial design

Treatments tested in this trial

  • Myoinositol
  • Levo-Carnitine

Treatment groups

72 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Mst.Sumyara Khatun

Lead sponsor

Bangladesh Medical University

Sponsor institution