Effect of Opioid-sparing Anesthesia on Quality of Recovery After Emergency Laparotomy
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-65
SponsorCairo University
About this trial
Opioids are widely used during anesthesia for pain control, but they cause many side effects-such as nausea, constipation, respiratory depression, dependence, and delayed recovery. They can also worsen low blood pressure in patients with unstable circulation. Because of these risks, multimodal analgesia is recommended to reduce opioid use.
Research on other non-opioid options is limited. Systemic lidocaine offers anti-inflammatory and opioid-sparing benefits and improves recovery in elective colorectal surgery, but its role in emergency laparotomy is still unclear and requires further study.
Eligibility criteria
Qualifiers
Adult patients (21-65 years), ASA I-III undergoing emergency laparotomy with midline incision
Disqualifiers
Severe cardiac morbidities (impaired contractility with ejection fraction < 45%, heart block, arrhythmias, tight valvular lesions)
Patients on vasopressor infusion, patients with high shock index (heart rate / systolic blood pressure >1)
Body mass index <18 or > 35 Kg/m2,
Pregnant or lactating women,
Trial design
Treatments tested in this trial
- Lidocaine (drug)
- Fentanyl (IV)
Treatment groups
120 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov