This study employs a Randomized Controlled Trial (RCT) design. Patients diagnosed with oral cancer by the attending physician and who meet the inclusion criteria will be admitted to the study after receiving a full explanation of the study objectives, intervention methods, potential risks, and participant rights from the research team upon their stable transfer to the plastic surgery ward post-operation. Written consent will be obtained from the patient and/or their legally authorized representative after adequate informed consent has been provided, before they are enrolled in the study.
Diagnosed with oral cancer and receiving microsurgical free flap reconstruction.
Age 18 years or older.
Conscious and able to follow study instructions.
Able to communicate without difficulty in Mandarin, Taiwanese, or through written communication.
Abnormal salivary gland function or severe xerostomia.
Recent use of antibacterial mouthwash or antibiotic therapy that may affect oral microbiota.
Presence of severe bacterial or viral oral infections, or significant periodontal disease.