Allergy prevalence is increasing steadily with some describing as the "epidemic of the twenty-first century". Maternal diet during pregnancy has been linked to offspring allergy risk, so it represents a potential target for allergy prevention. The Mediterranean Diet (MD) is considered one of the healthiest dietary models which exerts regulatory effects on immune system, due to the synergistic and interactive combinations of nutrients. We aim to study the effects of MD in pregnancy on the onset of allergic diseases at 2 years of age in the offspring.
None
concomitant presence of infections;
concomitant presence of malignancies;
concomitant presence of major gastrointestinal malformations;
concomitant presence of immunodeficiencies;
Parallel
Nutritional intervention based on Mediterranean Diet
Other interventionA personalized nutritional counseling and a tailored diet, according to Mediterranean dietary pattern, designed on the pre-pregnancy weight, height and trimester of pregnancy provided by certified dietitians.
Occurrence of allergic disorders at 24 months of age in the offspring
The evaluation of the effect of Mediterranean Diet during pregnancy on the occurrence of allergic disorders at 24 months of age in the offspring
Maternal weight gain
The evaluation of the effect of Mediterranean Diet during pregnancy on maternal weight gain
Pregnancy complications occurrence
The evaluation of the effect of Mediterranean Diet during pregnancy on pregnancy complications occurrence
Perinatal complications occurrence
The evaluation of the effect of Mediterranean Diet during pregnancy on perinatal complications occurrence
Neonatal birth weight
The evaluation of the effect of Mediterranean Diet during pregnancy on neonatal growth indices
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