Efficacy and Safety of Plasma Adsorption Combined With EVT for AIS-LVO
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorYi Yang
About this trial
The purpose of this study is to determine the efficacy and safety of plasma adsorption for patients of acute ischemic stroke who underwent endovascular thrombectomy due to large vessel occlusion of anterior circulation.
Eligibility criteria
Qualifiers
Age 18-80 years, male or female.
Diagnosis of acute ischemic stroke within 12 hours of symptom onset, underwent endovascular thrombectomy (EVT) adhering to current guidelines for large vessel occlusion in the anterior circulation (confirmed by DSA as ICA,MCA-M1,MCA-M2,ACA-A1,ACA-A2 occlusion or tandem lesion) and achieve successful recanalization (mTICI grade 2b/3).
Baseline NIHSS after EVT ≥ 6 and ≤25 points.
Randomization and the first plasma adsorption can be initiated within 12 hours after EVT.
Disqualifiers
Imaging after EVT indicated malignant brain edema with midline shift or brain herniation and surgical treatment was planned.
Parenchymal hemorrhage type 1, or type 2 confirmed by CT.
Allergic to any ingredient of the plasma separator, the adsorption device, or the piping.
Contraindications to plasma adsorption, platelet count <60×10^9/L,white blood cell<4×10^9/L, uncontrolled hypertension with persistent systolic blood pressure ≥200 mmHg or diastolic blood pressure ≥110 mmHg, uncontrolled hypotension, systolic blood pressure <90 mmHg or diastolic blood pressure <60 mmHg.
Trial design
Treatments tested in this trial
- Plasma adsorption
- Endovascular Thrombectomy
Treatment groups
100 Participants
are divided into 2 treatment groupsSponsors and collaborators
Yi Yang
Lead sponsor
The First Hospital of Jilin University
Sponsor institution
Source ClinicalTrials.gov