Efficacy of Add-on Plasma Exchange As an Adjunctive Strategy Against Septic Shock
ConditionSeptic Shock
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorHannover Medical School
About this trial
Randomized, prospective, multicenter, open-label, controlled, parallel-group interventional trial to test the adjunctive effect of therapeutic plasma exchange in patients with early septic shock.
Eligibility criteria
Qualifiers
New onset of septic shock (< 24 hrs), (SEPSIS-3 definition)
Norepinephrine (NE) dose ≥ 0.4 μg/kg/min ≥ 30 min OR NE ≥ 0.3 μg/kg/min + vasopressin (any dose)
Established vascular access suitable for plasma exchange independent of study inclusion (due to established indication of RRT, expected need for RRT within the next 48 hours or other medical reasons as assessed by treating physician team)
Disqualifiers
Age < 18 or > 80 years
Urogenital focus of infection
Pregnancy
Heparin-induced thrombocytopenia
Trial design
Treatments tested in this trial
- Therapeutic Plasma Exchange (TPE)
Treatment groups
274 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov