About this trial
The primary purpose of this study is to determine if intrathecal morphine (ITM) administration is superior to quadratus lumborum block or surgeon administered transversus abdominis plane (TAP) blocks result in decreased time to initiation of chemotherapy following oncologic surgery.
The secondary objectives of this study are to determine:
* The difference between interventions in time to return of bowel function in days * The difference between interventions in incidence of opioid related adverse drug events (ORADEs) * The difference between interventions in cumulative and post-operative total morphine milligram equivalents * The difference between interventions in quality-of-life assessment tool and patient satisfaction (brief pain index short form BPI-sf9) * The difference between interventions in hospital length of stay in days * The difference between cumulative pain scores between interventions * The difference between short acting and long-acting bupivacaine in pain management and time to chemotherapy
The hypothesis is that preoperative intrathecal morphine administration will significantly reduce the time to initiation of postoperative chemotherapy.
Eligibility criteria
Qualifiers
18-80 years of age
Patients undergoing open surgery for foregut, HPB, and colorectal cancer
Able to read and understand study procedures
Willing to participate and sign an ICF
Disqualifiers
Chronic Opioid Use (received an opioid within 90 days preoperatively)
Recreational Drug Use
Patients with cognitive impairments that can affect their ability to give consent
Patients that are currently taking anti-coagulants <7 days prior to surgery
Trial design
Treatments tested in this trial
- Intrathecal Morphine Block
- Bilateral Quadratus Lumborum Block
- Bilateral Transverse Abdominis Plane Block