This study aims to evaluate the clinical efficacy and safety of electroacupuncture (EA) in treating Generalized Anxiety Disorder (GAD). Participants will be randomly assigned to an EA group, a sham EA group, or a waiting-list control group. All participants will continue their routine medication (Paroxetine). The primary goal is to observe the reduction in anxiety symptoms using the Hamilton Anxiety Scale (HAMA). Additionally, the study will use functional MRI (fMRI) and Magnetic Resonance Spectroscopy (MRS) to explore the brain mechanisms through which EA helps alleviate anxiety.
Meet the DSM-5 diagnostic criteria for Generalized Anxiety Disorder (GAD).
No antidepressant or anti-anxiety medication in the past 2 weeks.
HAMA score ≥ 14.
Right-handed（for MRI).
Complicated with severe cardiovascular, cerebrovascular, or organic diseases.
History of other psychiatric disorders (e.g., schizophrenia, bipolar disorder).
Contraindications for MRI (e.g., metal implants, claustrophobia).
Pregnancy or lactation.
Lishu Gao
Lead sponsor
First People's Hospital of Hangzhou
Sponsor institution