Evaluation of Multi-Cancer Early Detection Testing in a High-Risk Military Population: The Sentinel Study

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age45+
SponsorDana-Farber Cancer Institute

About this trial

The purpose of this research study is to evaluate the possible benefits of an investigational, but commercially available Galleri multi-cancer early detection (MCED) blood test which is designed to detect many types of cancer early in veterans who have served in the military in active duty.

The name of the screening blood test being studied is:

-GRAIL Galleri MCED test

Eligibility criteria

Qualifiers

Active-duty or National Guard/Reserves military service for four or more years

Age ≥ 45

Received care at a VA facility within past 5 years

Able to sign informed consent

Disqualifiers

Individuals diagnosed with invasive malignancy within 3 years of enrollment (non- melanoma skin cancer is acceptable)

Individuals with evidence of symptomatic or active cancer requiring therapeutic intervention at the time of participation (hormone therapy for breast/prostate cancer is acceptable)

Individuals in the process of being evaluated for a clinical suspicion of cancer

Trial design

Treatments tested in this trial

  • GRAIL Galleri

Treatment groups

1,500 Participants
are divided into 1 treatment group

Sponsors and collaborators

Dana-Farber Cancer Institute

Lead sponsor

United States Department of Defense

Collaborator