Evaluation of the Efficacy of Transcranial Magnetic Stimulation on Resistant Auditory Hallucinations in Schizophrenia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorDominique JANUEL
About this trial
This open naturalistic study aims to evaluate the efficacy of rTMS in routine practice on auditory resistant hallucinations (AHR) of patients with schizophrenia. To this end, two stimulation methods will be offered to patients: the rTMS stimulation method and the cTBS stimulation method.We principally use the AHRS scale to evaluate the effectiveness of rTMS on RAH in patients with schizophrenia. Our main hypothesis is that rTMS used under naturalistic conditions, in addition to antipsychotics, would allow a relative improvement of resistant auditory hallucinations assessed by the AHRS scale between baseline and end of treatment in patients with schizophrenia.
Eligibility criteria
Qualifiers
Patient over 18 years of age
Patient diagnosed with schizophrenia according to DSM-V criteria (Diagnostic and Statistical Manual of Mental Disorder V5, 2013)
Presence of auditory hallucinations: Resistant auditory hallucinations: resistance to treatment with 2 different well-conducted antipsychotics.
Patient agreeing to participate in the study and having signed an informed consent
Disqualifiers
Have a contraindication to MST: intracranial foreign body, unstabilized epilepsy, cochlear implant
Presence of an unstabilized medical condition
Pregnant woman (Women of childbearing age without effective contraception)
Current or less than one month old engagement in another research protocol
Trial design
Treatments tested in this trial
- The rTMS method
- The cTBS method
Treatment groups
30 Participants
are divided into 2 treatment groupsSponsors and collaborators
Dominique JANUEL
Lead sponsor
Centre hospitalier de Ville-Evrard, France
Sponsor institution
Source ClinicalTrials.gov