This study aims to evaluate the efficiency of intermittent enteral nutrition versus continuous enteral nutrition to prevent from organ failures for patients at the acute phase of sepsis shock with mechanical ventilation in ICU.
Patient admitted in ICU for less than 48h, with invasive mechanical ventilation predicted for at least 48h, that can undergo nasogastric feeding for 7 days.
Patient under vasopressive drugs
Adult patients (age ≥ 18 years)
Informed person who has read and signed their consent
Contraindication to enteral nutrition and/or nasogastric tube insertion: esophageal varices and occlusive syndrome
Artificial enteral nutrition that cannot be initiated within 48 hours of intubation
Enteral nutrition ongoing for more than one hour at the time of inclusion
Need for exclusive or supplemental parenteral nutrition
Parallel
Intermittent enteral nutrition
Other interventionPatients will receive intermittent enteral nutrition, defined as 3 60-minute administrations every 8 hours.
Evolution of variation of the SOFA (Sepsis-related organ failure assessment) score.
Comparison of variation of the SOFA score between patients with intermittent nutrition versus patients with continuous nutrition.
evaluation of caloric intake
evaluation of caloric intake (kcal/day)
evaluation of protein intake
evaluation of protein intake (g/kg/day)
Measurement of nutritionnal status
measurement of weight (kg)
Evaluation of the digestive tolerance
Number of vomit (number)
Click on the lead sponsor to view all of their trials.
University Hospital, Rouen
Lead sponsor
University Hospital, Lille
Collaborator
University Hospital, Caen
Collaborator
Amiens University Hospital
Collaborator
Centre Hospitalier Saint-Philibert, GHICL
Collaborator
Centre Hospitalier Intercommunal Elbeuf-Louviers-Val de Reuil
Collaborator
Groupe Hospitalier du Havre
Collaborator
Centre Hospitalier de Dieppe
Collaborator
