Examining Olive Oil Extract on Knee Comfort and Function

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-75
SponsorApplied Food Sciences Inc.

About this trial

The goal of this study is to learn if an olive oil extract works to improve knee pain and discomfort in adults. The main questions it aims to answer are: 1) Does the olive oil extract improve the perceptions of knee pain and discomfort, and 2) Does the olive oil extract improve knee function in adults?

The main procedures in the study include:

* Screening and informed consent * Take one assigned study capsule (supplement or placebo) daily with food for 6 weeks * Complete digital questionnaires about your knee pain, stiffness, and function at scheduled times * Complete a Day 1 acute assessment and two simple functional movement tests at home as described below * If possible, connect a compatible wearable device to allow collection of sleep and physical activity data as detailed below. * Collect saliva samples at home using a provided kit at designated timepoints * Record any pain medications taken during the study or any side effects

Eligibility criteria

Qualifiers

Adults aged 40 to 75 years

Self-reported knee discomfort for at least 3 months

Willing and able to take one study capsule daily for the duration of the study

Willing and able to complete digital questionnaires, functional movement tasks, and other study activities using the Alethios platform

Disqualifiers

Diagnosis of inflammatory joint disease (e.g., rheumatoid arthritis) or other systemic inflammatory conditions affecting the knee

Any current or prior diagnosis from a licensed medical provider of knee disease

Knee surgery or significant knee injury within the past 6 months

Planned knee surgery during the study period

Trial design

Treatments tested in this trial

  • Olive Oil Extract
  • Placebo

Treatment groups

168 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Applied Food Sciences Inc.

Lead sponsor

Alethios, Inc.

Collaborator