Exercise and Protein Efficiency in T2D
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65+
SponsorUniversity of Illinois at Urbana-Champaign
About this trial
In this randomized controlled trial, 30 older adults (aged\> 65 years; 15 with T2D, 15 controls) will participate in a 12-week progressive exercise training program. They will undergo pre- and post-testing that includes body composition measures; oral glucose tolerance testing; cardiovascular fitness and muscle performance testing; dietary protein efficiency assessed using the indicator amino acid oxidation (IAAO) method; and a gut microbiota trial. The dietary protein efficiency trial will include repeated ingestion of crystallized amino acids (drink) containing stable isotopes, urine samples, and breath samples. The gut microbiome trial will consist of a single ingestion of a Mediterranean-based modeled meal enriched with 13C-phenylalanine (in the drink) and repeated blood draws. Participants will also be asked to give a fecal sample after the gut microbiome trial.
Eligibility criteria
Qualifiers
At least 65 years old
Body mass index: 25-40 kg/m²
Female: Waist to hip ratio >0.8
Male: Waist to hip ratio >1.0
Disqualifiers
Uncontrolled diabetes (evidence of HbA1c > 10%, prescription of insulin)
Diagnoses of diabetic neuropathy or failing diabetic neuropathy screening
Statins
Peripheral edema Consumption of ergogenic-levels of dietary supplements that may affect muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic/catabolic pro-hormones (e.g., DHEA) within 6 weeks prior to participation.
Trial design
Treatments tested in this trial
- 12 week progressive exercise training
Treatment groups
30 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Illinois at Urbana-Champaign
Lead sponsor
American Diabetes Association
Collaborator
Source ClinicalTrials.gov