Extracellular Vesicles for Rejection Monitoring in Cardiac Transplantation
ConditionRejection Heart Transplant
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorLaurenz Kopp Fernandes
About this trial
This study will analyze extracellular vesicle (EV)-derived protein profiles in heart transplantated patients during the first 15 months post-transplantation to investigate, if there are distinct EV-derived proteins or protein patterns that allow early and reliable diagnosis of acute cardiac allograft rejection. Additionally, it will explore temporal changes in the EV-derived protein profile during the early postoperative period irrespective of acute allograft rejection, and will investigate, if there are correlations between EV protein markers and imaging findings.
Eligibility criteria
Qualifiers
Subject is either on the heart transplant waiting list or is still hospitalised following HTx surgery.
Age of subject is ≥ 18 years.
Subject is female or male.
Capacity to consent.
Disqualifiers
Concurrent multiple solid organ or tissue transplants.
Prior history of any organ or cellular transplantation.
Subject suffers from an addiction or from a disease that prevents the subject from recognising nature, scope, and consequences of the study.
Subject shows an inability to comply with all the study procedures and follow-up visits.
Trial design
Treatments tested in this trial
- Not listed
Trial groups
30 Participants
are grouped into 1 trial groupSponsors and collaborators
Laurenz Kopp Fernandes
Lead sponsor
Charite University, Berlin, Germany
Sponsor institution
Source ClinicalTrials.gov