This randomized, sham-controlled, crossover study investigates the acute autonomic effects of transcutaneous cervical vagus nerve stimulation (tcVNS) applied at five different frequencies (0 Hz/sham, 10 Hz, 25 Hz, 50 Hz, 100 Hz) in healthy adults. The primary objective is to determine how stimulation frequency modulates heart rate variability (HRV), blood pressure, and respiratory rate. The study aims to establish a frequency-specific dose-response model using validated physiological measurements.
18-30 years
Healthy (self-reported)
No cardiovascular, neurological, metabolic or psychiatric disorders
No regular medication affecting autonomic function
Pregnancy
Cardiac arrhythmia
Hypertension or hypotension
Chronic respiratory disorders
SEFA HAKTAN HATIK
Lead sponsor
Sinop University
Sponsor institution