GLS in Difficult CPB Weaning

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorKartal Kosuyolu Yuksek Ihtisas Education and Research Hospital

About this trial

The goal of this observational study is to learn whether global longitudinal strain (GLS), measured by echocardiography, can predict difficulty separating from cardiopulmonary bypass (CPB) in adults undergoing elective cardiac surgery.

The main questions it aims to answer are:

* Can preoperative GLS measurement predict difficult separation from CPB? * Are GLS values associated with outcomes such as intensive care unit (ICU) stay, hospital stay, cardiac biomarkers, or 30-day mortality?

Participants will:

* Undergo standard cardiac surgery requiring CPB * Have echocardiographic assessments (TTE before and after surgery) * Have their recovery and outcomes monitored, including ICU and hospital stay, postoperative labs, and survival within 30 days

Eligibility criteria

Qualifiers

Age > 18 years.

Scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB).

Provided written informed consent to participate.

Isolated mitral valve replacement or repair.

Disqualifiers

Emergency cardiac surgery.

Redo cardiac surgery.

Contraindications to transesophageal echocardiography (TEE).

Ongoing inotropic drug therapy.

Trial design

Treatments tested in this trial

  • Myocardial strain imaging

Treatment groups

213 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital

Lead sponsor

University of Rome Tor Vergata

Collaborator

San Raffaele University Hospital, Italy

Collaborator