GROW-ICAS (Gut microBiota and prOgnostic Outcomes in IntraCranial Arterial Stenosis) is a prospective observational cohort study that enrolls patients with intracranial arterial stenosis to investigate the correlations between their gut microbiota, metabolomic, and transcriptomic profiles and three key clinical domains: functional outcomes, vascular plaque imaging characteristics, and post-stroke non-motor dysfunctions (including cognitive impairment, depression, anxiety, and fatigue).
Age 30-80 years.
Intracranial arterial stenosis confirmed by CTA/MRA/DSA.
Local residency ≥6 consecutive months.
Signed informed consent.
Tandem extracranial stenosis (≥50%) proximal to the target intracranial stenotic vessel.
Non-atherosclerotic intracranial stenosis.
Extracranial/intracranial endovascular treatment within 30 days pre-enrollment or planned intervention within 6 months.
Intracranial hemorrhage within 90 days pre-enrollment.