To observe the clinical effect and safety of transcranial electrical stimulation on patients with refractory epilepsy before and after treatment and analyze its therapeutic mechanism.
Clinical diagnosis of refractory epilepsy
Right-handed and aged 18-50 years old and primary school education or above;
No major neurological or mental illness, no head injury, alcohol dependence or drug dependence;
During the experiment, the subjects did not smoke, drink, get sick and take psychotropic drugs, and there were no major life events that caused mood changes.
organic brain injury, neurological diseases or serious physical diseases;
Have a history of substance abuse and drug dependence, or have used antipsychotic drugs in the past three months, and have serious suicidal tendencies;
There are contraindications for MRI or EEG or transcranial magnetic stimulation.