HYPoxaEmic Respiratory Failure and Awake Prone Ventilation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorVilnius University
About this trial
The goal of this prospective multi-centre randomised controlled trial is to determine if addition of awake prone positioning to standard oxygen, high flow oxygen therapy and non-invasive ventilation may reduce the rates of endotracheal intubation and mechanical ventilation.
Eligibility criteria
Qualifiers
Adult patients admitted to intensive care unit for acute hypoxemic respiratory failure.
Acute hypoxemic respiratory failure is defined by respiratory rate ≥25 breaths/min, and partial pressure of oxygen in the arterial blood (PaO2)/fraction of inspired oxygen (FiO2) ≤300 mm Hg or oxygen saturation (SpO2)/fraction of inspired oxygen (FiO2) ratio <235 while spontaneously breathing under standard oxygen with oxygen flow rate of at least 10 L/min, high flow oxygen therapy or non-invasive ventilation. For patients under standard oxygen, FiO2 is calculated according to the following formula: FiO2=0.21 + 0.03 per litre of supplemental oxygen.
Informed consent
Disqualifiers
impaired consciousness - Glasgow coma score <14;
inability to cooperate or prone position intolerance;
immediate indications for endotracheal intubation;
patients with do-not-intubate order at time of inclusion;
Trial design
Treatments tested in this trial
- Awake prone position (APP)
Treatment groups
262 Participants
are divided into 2 treatment groupsSponsors and collaborators
Vilnius University
Lead sponsor
Vilnius University Hospital Santaros Klinikos
Collaborator
Source ClinicalTrials.gov