Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexMale
Age45-75
SponsorAssistance Publique Hopitaux De Marseille
About this trial
Sepsis is a multifactorial syndrome characterized by a dynamic course and a clinical outcome dependent on several factors, and responsible for one in five deaths worldwide. The aim of this trial is to identify new prognostic markers for the progression of sepsis to septic shock, by comparing epigenetic markers between patients who have or have not developed severe forms of sepsis.
The main objective of this preliminary study is to identify prognostic markers for the progression of sepsis to septic shock, i.e. to compare targeted markers between subjects with sepsis who progress to septic shock versus subjects with sepsis who do not progress to septic shock.
Eligibility criteria
Qualifiers
Male patients,
Patients between 45 and 75 years of age,
Patients undergoing major esophageal or digestive carcinological surgery,
Patients with post-operative gram-negative bacterial sepsis (proven or suspected in the context of organ failure).
Disqualifiers
patients under 45 and aged 76 and over,
female patients,
non-carcinological or minor surgery,
non-esophageal or non-digestive surgery,
Trial design
Treatments tested in this trial
- blood sampling
Treatment groups
25 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov