Health Trials

Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis

ConditionsMultiple Sclerosis (MS)Relapsing-remitting Multiple Sclerosis (RRMS)Secondary-progressive Multiple Sclerosis (SPMS)Primary Progressive Multiple Sclerosis (PPMS)
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorUniversity Hospital, Basel, Switzerland

About this trial

This project is to:

1. Quantify differences in axonal integrity and organization in aMS versus naPMS patients. 2. Quantify changes in axonal integrity and organization in aMS versus naPMS patients over a two-year period. 3. Validate the combination of imaging parameters that best differentiate aMS versus naPMS patients using histopathology.

Eligibility criteria

Qualifiers

active RRMS (n=100): Relapsing-remitting course and > 1 clinical relapse and/or signs of MRI activity (> 1 Gd enhancing lesion) during the last year before study enrollment.

non-active PMS (n=100): Progressive course (PPMS or SPMS) and no clinical relapses and/or signs of MRI activity during the last year before study enrollment.

Age 18-80 years old

No other neurological or psychiatric disorder

Disqualifiers

Pregnancy

Contraindication to MRI (eg, claustrophobia, metallic implants, pacemaker etc).

Inability to give consent

Trial design

Treatments tested in this trial

  • MRI
  • Neurocognitive examination for healthy subjects
  • blood sampling

Treatment groups

300 Participants
are divided into 2 treatment groups

Sponsors and collaborators

University Hospital, Basel, Switzerland

Lead sponsor

Swiss National Science Foundation

Collaborator

Source ClinicalTrials.gov