Immune Dynamics in the Natural History of Chronic HBV Infection
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-80
SponsorNanfang Hospital, Southern Medical University
About this trial
The purpose of this observational study is to follow up on chronic HBV-infected patients over a long period of time to understand the changes in the immune status as age increases and the natural history of chronic HBV infection progresses. The main questions it aims to answer are:
* Does the natural history of chronic HBV infection progress with changes in HBV-specific immunity? * What is the role of age in the natural history of chronic HBV infection?
Patients with chronic HBV infection who are untreated and aged 1-80 years will be followed up every six months. During each follow-up, HBV-related serological and virological indicators will be tested. Peripheral blood samples will also be collected to test HBV-specific immunity and the immune environment.
Eligibility criteria
Qualifiers
Aged 1-80 years, either male or female.
Patients diagnosed with chronic hepatitis B virus infection in accordance with the "Guidelines for the Prevention and Treatment of Chronic Hepatitis B" (2019 edition).
No antiviral treatment (including nucleoside analogs and interferons, etc.) within the past six months.
Disqualifiers
Severe Underlying Diseases. Exclusion of patients with severe underlying diseases that affect the body's immune status.
Trial design
Treatments tested in this trial
- Venipuncture
Treatment groups
5,000 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov