Health Trials

Chronic Hep B

2

Review clinical trials related to Chronic Hep B. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Phase 1b, Open-label Study of Tune-401 to Assess Safety, PK and PD in Adults With Chronic Hepatitis B

This study will be conducted to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of Tune-401 in adult participants with Chronic Hepatitis B.

Participants needed: 36
Trial details
Phase: Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: Tune Therapeutics, Inc.Updated: Jan 6, 2026Locations: 3
Eligibility criteria

M/F, BMI ≥ 18.5 kg/m² at screening, age 18-75, inclusive [+3]

ALT/ AST ≥ 1.5 × upper limit of normal (ULN) and total bilirubin ≥ 1. 5 × ULN [+2]

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Status: Recruiting

Immune Dynamics in the Natural History of Chronic HBV Infection

The purpose of this observational study is to follow up on chronic HBV-infected patients over a long period of time to understand the changes in the immune status as age increases and the natural history of chronic HBV infection progresses. The main questions it aims to answer are: * Does the natural history of chronic HBV infection progress with changes in HBV-specific immunity? * What is the role of age in the natural history of chronic HBV infection? Patients with chronic HBV infection who are untreated and aged 1-80 years will be followed up every six months. During each follow-up, HBV-related serological and virological indicators will be tested. Peripheral blood samples will also be collected to test HBV-specific immunity and the immune environment.

Participants needed: 5,000
Trial details
Age: 1-80Biological sex: AllType: ObservationalSponsor: Nanfang Hospital, Southern Medical UniversityUpdated: Sep 30, 2025Locations: 1Duration: 3 Years
Eligibility criteria

Aged 1-80 years, either male or female. [+2]

Severe Underlying Diseases. Exclusion of patients with severe underlying disease...

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