This is an observational, retro-prospective, moncentric study focused on Inborn Errors of Immunity, an heterogeneous group of inherited diseases due to defects in the differentiation and/or function of the immune system. The primary aim of this study is to obtain a clinical-immunological, functional and molecular characterisation of paediatric and adult patients with confirmed or suspected Inborn Errors of Immunity, particularly of patients with manifestations of immunedysregulation, focusing on clinical course, immunophenotypic laboratory and functional abnormalities, genetic background.
patients with confirmed or suspected Inborn Errors of Immunity;
age < 50 years at onset of clinical features suspected for Inborn Errors of Immunity;
obtaining informed consent from patients or parents/legal guardian of pediatric patients.
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