sICASBLM is a prospective controlled trial, to asses the impact of improving blood lipid management on clinical outcome of moderate to severe symptomatic intracranial atherosclerotic stenosis patients (LDL-C\>1.8mmol/L) without endovascular therapy.
Age ≥18 years
Symptomatic intracranial atherosclerotic stenosis of moderate to severe, did not receive intravenous thrombolysis, thrombectomy, stent implantation and other intravascular treatment
low density lipoprotein cholesterol > 70mg/dl (1.8mmol/L)
Receive 3T magnetic resonance angiography or multi-mode MR (high resolution is required), angiography can be included, and images for analysis can be obtained.
Contraindications to statins
There are contraindications to MRI examination or cannot accept MRI examination
Stenosis caused by vasculitis, arterial dissection and moyamoya disease
Patients with active bleeding or obvious bleeding tendency