About this trial
A physiological human nutrition includes circadian feeding and nighttime fasting during sleep. There is increasing evidence, that this natural fasting episode over nighttime majorly contributes to repair processes of the human body. So far, intensive care patients are normally enterally fed continuously, so that there is no circadian nutrition and no nighttime fasting. An enteral nutrition for 12 hours followed by a fasting period of 12 hours supported by exogenous ketone salts potentially improves the reconstitution of ICU patients compared to ICU patients who are continuously enterally fed.
Eligibility criteria
Qualifiers
written informed consent to participate in this study
admission to ICU
enteral nutrition
Disqualifiers
Severe liver dysfunction / liver failure (Child Pugh >7 points / category B)
Severe kidney dysfunction (KDIGO stage 3)
Total pancreatectomy / insulin dependent diabetes mellitus (IDDM)
Pregnancy / lactation
Trial design
Treatments tested in this trial
- Cyclic enteral feeding with nighttime fasting and exogenous ketone salt supplementation (ß-hydroxybutyrate)