This prospective cohort study examines the relationship between maternal methyl-nutrient status during pregnancy and offspring neurodevelopment. It integrates maternal dietary, biomarker, genetic, and microbiome data and follows children up to 24 months.
Aged 20-45 years
Singleton pregnancy
Receiving routine prenatal care at the study site and planning to deliver at Far Eastern Memorial Hospital
Diagnosed with major chronic diseases, including renal disease (defined as chronic kidney disease stage 3 or above or history of renal transplantation), liver disease (defined as liver cirrhosis or history of liver transplantation), or malignancy
Alcohol consumption during pregnancy
Diagnosed with eating disorders or psychiatric conditions that may impair the assessment of nutritional status
Diagnosed with congenital anomalies, epilepsy, or severe brain injury
Far Eastern Memorial Hospital
Lead sponsor
Fu Jen Catholic University
Collaborator