The primary objective of this study is to evaluate the efficacy of Mentalization-Based Treatment (MBT) combined with Need-Based Clinical Interventions (NBCI) compared to NBCI alone, on CHR-P diagnostic statuses and symptom expression (Hypothesis 1). Specifically, the investigator will assess diagnostic outcomes using a 3-level variable: transition to psychosis, CHR-P status quo, and remission out of CHR-P, as well as CHR-P symptom expression. The investigator hypothesize that: (1a) the experimental treatment (MBT + NBCI) will have a significant effect on diagnostic status (i.e. transition to psychosis) at the end of treatment and follow-up; (1b) the experimental treatment (MBT + NBCI) will significantly reduce the severity of psychotic symptoms at the end of treatment and follow-up.
Patients aged 14-30 years with a CHR-P condition, as defined by the SIPS criteria
Patients who provide informed consent
Patients with a prior diagnosis of a psychotic disorder
Intellectual disability (IQ < 70).
Patients whose psychotic symptoms are primarily induced by substance misuse.
Patients with significant language barriers
Marco Armando
Lead sponsor
Centre Hospitalier Universitaire Vaudois
Sponsor institution