Clinical trials

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Condition / disease
Location
Status: Recruiting

Mentalization Based Treatment (MBT) in Help Seeking Youths With a Clinical High-Risk Condition for Psychosis (CHR-P)

The primary objective of this study is to evaluate the efficacy of Mentalization-Based Treatment (MBT) combined with Need-Based Clinical Interventions (NBCI) compared to NBCI alone, on CHR-P diagnostic statuses and symptom expression (Hypothesis 1). Specifically, the investigator will assess diagnostic outcomes using a 3-level variable: transition to psychosis, CHR-P status quo, and remission out of CHR-P, as well as CHR-P symptom expression. The investigator hypothesize that: (1a) the experimental treatment (MBT + NBCI) will have a significant effect on diagnostic status (i.e. transition to psychosis) at the end of treatment and follow-up; (1b) the experimental treatment (MBT + NBCI) will significantly reduce the severity of psychotic symptoms at the end of treatment and follow-up.

Participants needed: 212
Trial details
Age: 14-30Biological sex: AllType: InterventionalSponsor: Marco ArmandoUpdated: Jul 1, 2026Locations: 1
Eligibility criteria

Patients aged 14-30 years with a CHR-P condition, as defined by the SIPS criteri... [+1]

Patients with a prior diagnosis of a psychotic disorder [+5]