Metabolic Fluid Responsiveness in Children

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age0-15
SponsorUniversity Hospital, Bordeaux

About this trial

The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery. This would allow physicians to identify which patient could benefit the most from fluid expansion, thus avoiding useless and potentially dangerous fluid expansions that could lead to fluid overload. To this end, The investigators will evaluate the diagnostic accuracy of the ratio of central venous to arterial carbon dioxide tension (Pv-aCO2) to arteriovenous oxygen content (CavO2), a simple biological marker of anaerobic metabolism, for the diagnosis of metabolic fluid responsiveness defined as a significant increase in oxygen consumption (VO2) after fluid expansion.

Eligibility criteria

Qualifiers

Age less than or equal to 15 years old

Hospitalization in a pediatric intensive care unit after cardiac surgery

Prescription by the attending physician of a fluid expansion of 10ml/kg

Prescription of arterial and venous blood gas before and after the volume expansion to help manage acute circulatory failure

Disqualifiers

Patient less than 37 weeks' corrected gestational age

Hemodynamic instability making the delay necessary for any test dangerous

Supine position contraindicated or deleterious

Impairment of echocardiographic acoustic window or restless patient making ultrasonography impossible

Trial design

Treatments tested in this trial

  • Not listed

Trial groups

No trial groups listed

Sponsors and collaborators