About this trial
Orthodontic treatment often requires moving the upper canine teeth (the pointed teeth) into the spaces left after removing premolar teeth. This process is usually slow and can take many months, making the total treatment time longer.This study will compare two techniques that may speed up this tooth movement:
Micro-osteoperforation (MOP): A minimally invasive procedure in which a small device is used to create tiny holes in the jawbone near the canine tooth under local anesthesia. These micro-perforations stimulate the bone to remodel faster, which allows the tooth to move more quickly.
Photobiomodulation therapy (PBMT) / Low-Level Laser Therapy (LLLT): A painless, non-invasive technique that uses a low-power laser light applied to the gum tissue near the canine tooth. The laser energy stimulates cells in the bone and supporting tissues to accelerate tooth movement without any cutting or drilling.
This trial will randomly assign eligible patients into one of three groups: MOP, LLLT, or a control group receiving standard orthodontic treatment only. Each group will contain 25 participants (75 total). The main goal is to measure and compare how fast the upper canine tooth moves in each group over the first month and until the space is fully closed. The study will also measure the effect of age and sex on the results. The findings will help orthodontists choose the best, fastest, and most comfortable method for each patient to shorten overall treatment time
Eligibility criteria
Qualifiers
Age 18 to 40 years at the time of enrollment
Systemically healthy with no chronic medical conditions affecting bone metabolism or wound healing
Requiring bilateral maxillary first premolar extraction as part of a comprehensive fixed orthodontic treatment plan
Class I or mild Class II malocclusion requiring maximum anchorage canine retraction
Disqualifiers
Systemic diseases affecting bone metabolism including osteoporosis, osteopenia, diabetes mellitus, thyroid disorders, or autoimmune conditions
Current use of medications affecting bone remodeling including corticosteroids, bisphosphonates, non-steroidal anti-inflammatory drugs (NSAIDs), or vitamin D supplements
Current or recent smokers (within the past 6 months)
Pregnant or breastfeeding women
Trial design
Treatments tested in this trial
- Micro-osteoperforation (MOP)
- Photobiomodulation Therapy using 976 nm Diode Laser
- Conventional orthodontic canine retraction