Health Trials

MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial

ConditionsLocally Advanced Cervical CarcinomaLocally Advanced Cervical CancerLocally Advanced Pancreas CancerLocally Advanced Pancreatic CarcinomaLocally Advanced Pancreatic CancerCervical CancerPancreas CancerPancreatic CancerCancer of the CervixCancer of the Pancreas
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorWashington University School of Medicine

About this trial

This study is a dynamically adjustable prospective longitudinal study designed to capture biospecimen (biopsy, blood, surgical) and multimodal treatment-related data (imaging, dosimetry, clinical) before, during, and after treatment with definitive-intent chemoradiotherapy for patients with locally advanced cervical and pancreatic cancer.

Eligibility criteria

Qualifiers

Cervical cancer

Pancreatic cancer

ECOG performance status ≤ 2

At least 18 years old

Disqualifiers

Any issue (medical, anatomic, other) that might preclude safe acquisition of biospecimens at the discretion of the treating physician

Trial design

Treatments tested in this trial

  • Tumor collection via biopsy
  • Blood collection
  • Diffusion basis spectrum imaging (DBSI) magnetic resonance imaging (MRI)

Treatment groups

60 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Washington University School of Medicine

Lead sponsor

National Cancer Institute (NCI)

Collaborator

The Foundation for Barnes-Jewish Hospital

Collaborator

Source ClinicalTrials.gov