MMP-2/3 and Periapical Healing Outcomes
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorTC Erciyes University
About this trial
This prospective randomized clinical study will investigate the association between MMP-2 and MMP-3 gene polymorphisms and radiographic healing outcomes following nonsurgical root canal treatment in patients with chronic apical periodontitis. A total of 50 patients will undergo standardized endodontic treatment and will be followed for 12 months. Genotyping will be performed using baseline DNA samples, and periapical healing will be assessed using the Periapical Index (PAI). The relationship between genetic variations and treatment outcomes will be analyzed to determine whether host-related genetic factors influence healing patterns after root canal therapy.
Eligibility criteria
Qualifiers
Single-rooted teeth
PAI score ≥ 3
Fully developed root apices
Periodontal probing depth less than 5 mm
Disqualifiers
Previous endodontic treatment in the selected tooth
Diagnosis of symptomatic apical abscess
Presence of root fracture or internal/external resorption
Use of systemic antibiotics within the previous 4 weeks
Trial design
Treatments tested in this trial
- Nonsurgical Root Canal Treatment
Treatment groups
50 Participants
are divided into 1 treatment groupLocations
Sponsors and collaborators
Source ClinicalTrials.gov