Mood and Thought Process Study

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorButler Hospital

About this trial

The primary objective for this project is to test whether affective executive functioning is a mechanism of action of mindfulness-based cognitive therapy and Wellness for Wellbeing. The main questions it aims to answer are:

1. Test the effect of MBCT vs. Wellness for Wellbeing on affective inhibition (i.e., emotionally valenced inhibition as measured via the affective Go/No Go task) using an RCT. 2. Test the effect of MBCT vs. Wellness for Wellbeing on (a) affective updating and (b) affective shifting. Outcomes will be measured with the affective n-Back and the affective Internal Switching Task, respectively.

3a) The investigators will examine whether depression symptom severity co-varies with change in affective executive functioning (i.e., affecting inhibition, shifting, and updating) over time. 3b) The investigators will examine whether compliance with treatment protocol (e.g., number of classes attended, amount of home practice) predicts endpoint executive functioning.

Participants will complete surveys, interviews, and computer tasks, and will be randomized to either Mindfulness-Based Cognitive Therapy or Wellness for Wellbeing.

Eligibility criteria

Qualifiers

Adults 18 years or older

English fluency in order to complete study procedures

Normal vision or corrected to normal vision

QIDS score ≥ 5 and ≤ 15 to include individuals with elevated, but not severe symptoms of depression

Disqualifiers

None

Trial design

Treatments tested in this trial

  • Mindfulness-Based Cognitive Therapy
  • Wellness for Wellbeing

Treatment groups

76 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Butler Hospital

Lead sponsor

National Center for Complementary and Integrative Health (NCCIH)

Collaborator