Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorImperial College London
About this trial
ORBITA-MOON is a double-blinded, placebo-controlled experimental study that aims to understand how the different coronary artery stenoses contribute to overall clinical angina in patients with multi-vessel coronary artery disease. This study will investigate the symptoms conferred by each stenosis, induced by experimental ischaemia, for 60 patients with multi-vessel coronary artery disease.
Eligibility criteria
Qualifiers
Eligibility for PCI due to angina
≥70% stenosis in two or more coronary arteries of ≥2.5mm visual diameter stenosis, on invasive coronary angiography (ICA)
Severe stenosis in ≥2 coronary arteries of ≥ 2.5mm visual diameter stenosis, on CTCA
dobutamine stress echocardiogram
Disqualifiers
Recent acute coronary syndrome
Previous coronary artery by-pass graft surgery (CABG)
Significant left main stem disease
Chronic total occlusion in the target artery(s)
Trial design
Treatments tested in this trial
- Percutaneous coronary intervention (PCI)
- Symptom assessment during experimentally induced ischaemia
Treatment groups
60 Participants
are divided into 1 treatment groupSponsors and collaborators
Imperial College London
Lead sponsor
Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust
Collaborator
Mid and South Essex NHS Foundation Trust
Collaborator
Imperial College Healthcare NHS Trust
Collaborator
St George's Healthcare NHS Trust
Collaborator
Royal Free Hospital NHS Foundation Trust
Collaborator
Source ClinicalTrials.gov