Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG)
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Cambridge
About this trial
The goal of this observational study is to to look for changes within the brain, and changes in body-to-brain signals in people with cancer and people who do not have cancer. The main questions it aims to answer are:
1. Are there differences in areas of the brain known to be related to appetite control, food reward and motivation, between participants with cancer related weight loss and healthy volunteers 2. Do responses to questionnaires and computer based tasks suggest participants with cancer related weight loss have reduced appetite and reduced motivation to eat compared to healthy volunteers, and if so, do questionnaires suggest that this is associated with any other symptoms?
Researchers will compare the structure and blood flow in relevant areas of the brain using MRI images between participants with cancer related weight loss and healthy volunteers. Participants will complete questionnaires and computer based tasks to allow researchers to assess areas of the brain which become more active in response to different stimuli. Some computer based tasks will be performed during the MRI scan. This is called functional MRI.
A further objective is to obtain an archive of blood samples which will be stored securely for future analysis if relevant hormones or analytes are identified that may be relevant to metabolism or body composition
Eligibility criteria
Qualifiers
Written informed consent
Aged 18 years or over
Willing and able to comply with study procedures and visits
Histological or cytological diagnosis of cancer or confirmed non-intracranial malignancy on imaging.
Disqualifiers
Non-fluent English speaker
Active infection, as determined by the investigator based on clinical symptoms and / or fever and / or requirement for antibiotics
Women, who are pregnant, plan to become pregnant or are lactating.
MRI contraindication
Trial design
Treatments tested in this trial
- MRI/ Functional MRI
- Self-reported questionnaires
- Computer based tasks
Treatment groups
50 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov