Neuroprotection Bundles For Comatose Survivors Following Cardiac Arrest
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorXiangya Hospital of Central South University
About this trial
The investigators designed LAPTOPS to determine the effectiveness of a goal-directed neuroprotection bundles of active management including body temperature,PaCO2,PaO2,position,Blood glucose ,blood sodium,Blood pressure and Lactate vs. usual care in adult post-cardiac arrest care.
LAPTOPS is a large-scale pragmatic clinical trial to provide reliable evidence over the effectiveness of a widely applicable goal-directed care bundle in acute phase of adult post-cardiac arrest care.
Eligibility criteria
Qualifiers
Age ≥ 18 years and < 80 years
Patients of in-hospital or out-of-hospital cardiac arrest who have returned -spontaneous circulation (ROSC) after cardiopulmonary resuscitation and do not require CPR for more than 20 minutes;
Patients who are unconscious after ROSC, defined as FOUR motor response score < 4 points or GSC ≤ 8 points;
Family members or legal representatives signed informed consent.
Disqualifiers
Unwitnessed cardiac arrest, estimated time from cardiac arrest to start of CPR > 30 minutes;
Time from cardiac arrest to ROSC > 60 minutes;
Patients who woke up immediately after ROSC by CPR;
End-stage diseases;
Trial design
Treatments tested in this trial
- Goal-directed care bundle for neuroprotection
- Usual Care
Treatment groups
1,008 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov