Optimized Diagnosis and Precision Medicine of MODY
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorTaichung Veterans General Hospital
About this trial
The goal of this observation is to establish a complete registry for the clinical manifestations, environment, genetic, and other related gene variation information of young-onset diabetic patients. Moreover, according to the physiological and pathological mechanisms of different genes, the impact on the clinical characteristics of diabetes, the therapeutic response to drugs, and the impact on complications will be analyzed.
The main questions are:
1. The distribution of different types of MODY 2. The phenotypes and clinical characteristics of different types of MODY 3. Response to antidiabetic drugs among different types of MODY
Once the participant is enrolled, their questionnaire information (including disease course and development, health history, family history, drug history, etc.), medication, outpatient/inpatient medical history, etc. will be collected and logged in. Blood and urine samples will also be collected for biochemical tests genetic testing, etc.
At the same time, the investigators will conduct a continuous follow-up on a regular basis (3 months, 6 months, 12 months, 24 months, and 5 years after the study subject is enrolled).
Young-onset type 2 diabetes will be compared to see the difference in clinical presentations and responses to antidiabetic drugs.
Eligibility criteria
Qualifiers
Case Group Diagnosis of diabetes at or before 25 years of age. BMI (Body Mass Index) of 25 kg/m² or lower. Having at least one parent diagnosed with type 2 diabetes.
Family Group Direct blood relatives of the case group, including brothers and sisters of the case group, who have contacted the research team through the subjects.
Control Group Diagnosis of diabetes occurred at or before the age of 40, and the individual lacks typical MODY (Maturity-Onset Diabetes of the Young) characteristics.
Disqualifiers
Confirmed Diagnosed with type 1 diabetes.
Under 18 years of age.
Unable to personally provide informed consent.
Patients with unrelieved leukemia.
Trial design
Treatments tested in this trial
- Not listed
Trial groups
1,500 Participants
are grouped into 3 trial groupsSponsors and collaborators
Taichung Veterans General Hospital
Lead sponsor
National Health Research Institutes, Taiwan
Collaborator
Source ClinicalTrials.gov