Patient-specific Reconstruction Plate for Segmental Mandibular Defects
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorAlexandria University
About this trial
The mandible's horseshoe-shaped anatomy makes the reconstruction of segmental defects a challenging procedure. Conventional reconstruction typically relies on alloplastic plates to bridge bony stumps; however, these require extensive intraoperative bending, often resulting in imperfect adaptation, press-to-contact fixation, and residual stresses that increase the risk of hardware fatigue and fracture. Recent advances in computer-aided design and manufacturing (CAD/CAM) and virtual surgical planning (VSP) have improved precision in maxillofacial reconstruction. Patient-Specific Reconstruction Plates (PSRP), developed from virtual planning and patient-specific anatomical data, offer a bespoke contour adaptation, predictable screw positioning, and elimination of press-fit deformation. This customization improves alignment, mechanical stability, and long-term outcomes.
Eligibility criteria
Qualifiers
Patients with a segmental mandibular continuity defect, not involving the condyle.
Patients suffering from benign, locally invasive or malignant lesions that involving the lower border of the mandible.
Patients with recurrent lesions after resection.
Patients dealing with osteomyelitis or jaw osteonecrosis that is indicated for sequestrectomy.
Disqualifiers
Medically compromised patients contradict the operation.
Patients with segmental mandibular defects that require condylar process resection
Patients with lateral segmental mandibular defects involving the condyle that require reconstruction using an alloplastic total joint.
Patients with an active infection at the site of resection.
Trial design
Treatments tested in this trial
- Patient specific reconstruction plate
Treatment groups
14 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov