Dexamethasone for Ureteral STent Symptoms (DUSTS)
ConditionUreteral Stent-Related Symptom
Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18-70
SponsorThe Methodist Hospital Research Institute
About this trial
The purpose of this study to learn if high-dose dexamethasone, a type of long-acting steroid, works to decrease urinary symptoms and pain after ureteroscopy and stent placement for kidney stones. The main question it aims to answer is:
1\) Does high-dose steroid change the quality of life score on day 2 after surgery
Researchers will compare high-dose of dexamethasone (20 mg) to a standard dose of dexamethasone (4 mg) to see if a higher dose of the drug will help with urinary symptoms and pain
Participants will:
1. randomly receive 20 mg or 4 mg of dexamethasone (20 mg) at the time of surgery 2. fill out a questionnaire day 1 and day 2 after surgery 3. fill out a medication diary for one week after surgery 4. visit the clinic on day 2 after surgery for checkup 5. visit the clinic on day 4-7 after surgery for check up
Eligibility criteria
Qualifiers
Age 18-70 years old
Patients who are undergoing unilateral retrograde ureteroscopy (semi-rigid or flexible) with planned ureteral stent placement for treatment of renal/ureteral stones
Patients who can read and understand English
Patients who can follow up post-operatively within 7 days at Houston Methodist Hospital
Disqualifiers
Untreated UTI
HbA1c ≥6.5 on preoperative testing
Patients with prior diagnosis of any type of diabetes mellitus
Patients with immunosuppression, including chronic corticosteroid use
Trial design
Treatments tested in this trial
- Dexamethasone Sodium Phosphate Injection 20 mg
- Dexamethasone Sodium Phosphate Injection 4mg
Treatment groups
70 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov