Efficacy of Preconditioned Adipose-Derived Stem Cells in Fat Grafting
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-50
SponsorUniversity of the Punjab
About this trial
The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting to correct facial contour deformities that cause aesthetic complications in patients.
Eligibility criteria
Qualifiers
Age 18-50 years (male or female)
Body-mass index 20-30 kg/m²
Suitable for liposuction as assessed by the expected cosmetic results
Provided signed informed consent
Disqualifiers
Systemic disorders include autoimmune diseases, hemorrhagic diseases, bone marrow aplasia, sepsis, cancer, and others
Local disorders include acne, infections and others
Risk factors include smoking, uncompensated diabetes, hypertension, and allergy to the drugs used for general anesthesia
Microbiological contamination of either the cell culture or the transplanted tissue
Trial design
Treatments tested in this trial
- Cultured ASCs enrichment fat grafting
- Curcumin-preconditioned ASCs enrichment fat grafting
- Conventional fat grafting
Treatment groups
24 Participants
are divided into 3 treatment groupsSponsors and collaborators
University of the Punjab
Lead sponsor
Centre of Excellence in Molecular Biology, University of the Punjab, Lahore
Collaborator
Higher Education Commission (Pakistan)
Collaborator
Jinnah Burn and Reconstructive Surgery Centre, Lahore
Collaborator
Source ClinicalTrials.gov