About this trial
The aim of the study is to analyze over a 12 month-period, the safety and the efficacy of a circumferentiel oesophageal replacement of the esophagus by a decelularized human esophagus, in 24 patient with a short esophageal stenosis refractory to endoscopic dilatations.
Eligibility criteria
Qualifiers
Age: 18 to 65
Caustic, traumatic, anastomotic, post-operative, radiation-induced or post-endoscopic (mucosal resection, submucosal dissection) benign esophageal stricture refractory to endoscopic dilatation.
For women: effective contraception for the entire duration of the study (from signature of consent to end of follow-up)
Affiliated or beneficiary of a social security scheme.
Disqualifiers
Weight loss > 10% of body weight over last 3 months
Stenosis > 5 cm in length
Multiple strictures
Esophageal mouth stenosis
Trial design
Treatments tested in this trial
- Replacement of the esophagus with a decellularized human esophagus graft