First-in-Human Trial of VBC101 in Participants With Advanced Solid Tumor Malignancies
Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorVelaVigo Bio Inc
About this trial
This is a multicenter, open-label, multiple-dose, FIH Phase 1/2a trial. The Phase 1 portion adopts an accelerated titration for the first dose level, followed by BOIN design to identify the MTD and/or RP2D with potential backfill cohorts. The Phase 2a portion consists of dose optimization followed by cohort expansion to confirm safety and tolerability and to further evaluate the efficacy of the selected RP2D in selected solid tumor malignancies for VBC101.
Eligibility criteria
Qualifiers
1. The participant or the participant's legally acceptable representative is willing and able to provide a written ICF before initiating any trial procedure.
2. Histologically or cytologically confirmed unresectable advanced/metastatic solid tumor that has relapsed or progressed on or after standard systemic treatments, or is intolerable with standard treatment, or for which no standard treatment is available
3. At least one measurable lesion as assessed by the investigator according to RECIST v1.1criteria
4. Male or female adults (defined as ≥ 18 years of age)
Disqualifiers
2. Known or suspected brain metastases, or spinal cord compression, unless the condition has been treated, asymptomatic, and has been stable without requiring escalating doses of corticosteroids (equivalent to ≤10 mg/day prednisone) or anti-convulsant medications for at least four weeks prior for the first dose of investigational drug.
3. Prior treatment with an ADC targeting EGFR and/or cMet (including VBC101)
4. Prior treatment with any ADC carrying a TOP1i payload (including prior VBC101).
5. Has a medical history of interstitial lung diseases (e.g., non-infectious interstitial pneumonia, pneumonitis, pulmonary fibrosis, and severe radiation pneumonitis) or current interstitial lung diseases or who are suspected to have these diseases by imaging at screening.
Trial design
Treatments tested in this trial
- VBC101
Treatment groups
310 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov