Health Trials

Participants With Advanced Solid Tumor Malignancies

2

Review clinical trials related to Participants With Advanced Solid Tumor Malignancies. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Clinical Trial of VBC103 in Patients With Advanced Malignant Solid Tumors

This study is a multicenter, open-label, multi-dose, first-in-human (FIH) Phase I/IIa study to determine the safety and tolerability of VBC103, as well as the maximum tolerated dose (MTD) and/or recommended Phase II dose (RP2D), PK and further evaluate its efficacy.

Participants needed: 255
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: VelaVigo Bio IncUpdated: Apr 22, 2026Locations: 1
Eligibility criteria

1.The subject or their legal representative is willing and able to sign a writte... [+7]

1.Any unresolved ≥Grade 2 toxicity from prior anticancer therapy. [+3]

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Status: Recruiting

First-in-Human Trial of VBC101 in Participants With Advanced Solid Tumor Malignancies

This is a multicenter, open-label, multiple-dose, FIH Phase 1/2a trial. The Phase 1 portion adopts an accelerated titration for the first dose level, followed by BOIN design to identify the MTD and/or RP2D with potential backfill cohorts. The Phase 2a portion consists of dose optimization followed by cohort expansion to confirm safety and tolerability and to further evaluate the efficacy of the selected RP2D in selected solid tumor malignancies for VBC101.

Participants needed: 310
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: VelaVigo Bio IncUpdated: Apr 22, 2026Locations: 5
Eligibility criteria

1. The participant or the participant's legally acceptable representative is wil... [+9]

2. Known or suspected brain metastases, or spinal cord compression, unless the c... [+3]

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