Oral Changes With Caloric and no Caloric Sweeteners
Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age12-18
SponsorHospital Infantil de Mexico Federico Gomez
About this trial
The objective of this clinical trial is to compare the effect that the intake of beverages without sweeteners, added with non-caloric sweeteners (stevioside) and caloric sweeteners (sucrose) on oral pH and dental biofilm microbiome in Mexican adolescents.
Participants will drink on different occasions a beverage without sweetener, a beverage added with stevioside or a beverage added with sucrose. The researchers will compare the changes that each one causes in salivary pH, dental biofilm pH, dental biofilm bacterial proliferation and dental biofilm microbiome.
Eligibility criteria
Qualifiers
Habitual consumption of soft drinks
Decayed, Missing, and Filled Teeth (DMF) index of at least 3 (considering as caries those lesions that are visible without the tooth needing to be dry)
Agree to participate in the study and sign informed consent
Parents sign informed consent
Disqualifiers
Orthodontic treatment
Topical application of fluoride during the last 3 months
Having a motor disability that interfered with tooth brushing
Xerostomia
Trial design
Treatments tested in this trial
- Stevioside
- Sucrose
- Natural water
Treatment groups
52 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov