The goal of this clinical trial is to learn if the daily take of donepezil can treat adult patient suffering from anorexia nervosa. The main question it aims to answer is : do daily donepezil intake permit weight gain and reduction of food restriction rituals ? The treatment is a capsule comprising a drug limiting the degradation of a neurotransmitter called acetylcholine. This treatment has long been used to treat certain cognitive disorders. Researchers will compare two drug dosage and a look-alike capsule that contains no drug to see if the dose has an impact on the effect. Participants will take one capsule per day for three months will have regular hospital visits for cognitive and metabolic tests.
Female
Presence of the 3 DSM-V criteria for Anorexia Nervosa
Restrictive subtype of Anorexia Nervosa according to DSM-5
Body Mass Index between 15 and 18.5 kg/m²
Presence of one or more somatic criteria for hospitalization according to french HAS 2010 guidelines
Past diagnosis of anorexia nervosa with binge-eating/purging type
Past diagnosis of bulimia nervosa
Past diagnosis of binge-eating disorder
Centre Hospitalier St Anne
Lead sponsor
Université Paris Cité
Collaborator
Institut National de la Santé Et de la Recherche Médicale, France
Collaborator