The aim of this study is to verify the efficacy of in vitro induction of autologous decidual-like NK cells therapy for reproductive failure associated with uterine NK cells abnormalities.
Reproductive failure with abnormal endometrial natural killer (NK) cells in menstrual blood;
With a clear intention to conceive;
Normal ovarian function, or premature ovarian insufficiency with ≥2 high-quality cryopreserved embryos available for transfer;
Endometrial thickness measured by transvaginal ultrasound during the periovulatory period ≥7 mm;
Use of progesterone receptor modulators;
One of the couple's chromosomal karyotype abnormalities, with no euploid embryo identified via preimplantation genetic testing for aneuploidy;
Severe endometriosis or adenomyosis, uterine fibroids affecting uterine cavity morphology, uterine malformations, intrauterine adhesions, or thin endometrium;
Uncontrolled autoimmune or endocrine disorders;
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Lead sponsor
The University of Science and Technology of China
Collaborator
Sir Run Run Shaw Hospital
Collaborator
Second Affiliated Hospital of Soochow University
Collaborator
The First Affiliated Hospital of Anhui Medical University
Collaborator
The First Affiliated Hospital of University of Science and Technology of China
Collaborator