buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest

ConditionsHypoxia-Ischemia, Brain Heart Arrest Status Epilepticus Refractory Status Epilepticus Seizures Anoxic-Ischemic Encephalopathy Anoxia-Ischemia, Cerebral

Trial statusRecruiting

Trial phasePhase 2

Trial typeInterventional

Biological sexAll

Age18+

SponsorUniversity of California, San Francisco

About this trial

RESTORE is a randomized clinical trial investigating the safety and feasibility of using EEG treatment targets (burst suppression vs. seizure suppression) for post-cardiac arrest refractory status epilepticus treatment.

Eligibility criteria

Qualifiers

Age ≥18 years old

Non-traumatic, out-of-hospital cardiac arrest

Comatose on admission - defined as not following commands

Return of spontaneous circulation (ROSC) within less than 45 minutes

Disqualifiers

Acute cerebral hemorrhage or infarction

Pregnancy

Prisoners

Trial design

Treatments tested in this trial

Burst Suppression EEG Target Intravenous Anesthesia
Seizure Suppression EEG Target Intravenous Anesthesia

Treatment groups

30 Participants

are divided into 2 treatment groups

Sponsors and collaborators

University of California, San Francisco

Lead sponsor

The ZOLL Foundation

Collaborator

Source ClinicalTrials.gov