Carvedilol Versus Endoscopic Band Ligation for Primary Prophylaxis of Oesophageal Variceal Bleeding

ConditionEsophageal Varices

Trial statusRecruiting

Trial phasePhase 2, Phase 3

Trial typeInterventional

Biological sexAll

Age18+

SponsorSherief Abd-Elsalam

About this trial

Carvedilol versus endoscopic band ligation for primary prophylaxis of oesophageal variceal bleeding in cirrhotic patients with arterial hypertension

Eligibility criteria

Qualifiers

• Aged >18 years

Cirrhotic patients with arterial hypertension

Endoscopic evidence of medium/large-sized esophageal varices

Disqualifiers

• History of variceal bleeding or previous primary prevention of varices.

Portal vein thrombosis or previous porto-systemic shunts as TIPS.

Patients on drugs affecting portal pressure (beta blockers, nitrates).

Advanced cardiovascular disease including acute myocardial infarction, atrio-ventricular block, congestive heart failure, chronic peripheral ischemia, severe bradycardia.

Trial design

Treatments tested in this trial

Carvedilol
Endoscopic band ligation

Treatment groups

306 Participants

are divided into 2 treatment groups

Sponsors and collaborators

Sherief Abd-Elsalam

Lead sponsor

Tanta University

Sponsor institution

Source ClinicalTrials.gov