Chimeric Antigen Receptor Modified T Cells Targeting BCMA for the Treatment of Relapsed/Refractory Multiple Myeloma

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-80
SponsorThe First Affiliated Hospital of Xiamen University

About this trial

To evaluate the safety and tolerability of chimeric antigen receptor gene-modified T cells targeting BCMA for the treatment of relapsed/refractory multiple myeloma

Eligibility criteria

Qualifiers

Age 18-80 years, no gender restrictions;

Diagnosed with refractory/relapsed multiple myeloma through physical examination, pathological examination, laboratory tests, and imaging studies;

Flow cytometry or histology confirms positive BCMA expression in myeloma cells;

As judged by the investigator, the expected survival time is >3 months;

Disqualifiers

Pregnant or nursing women, as well as women planning to become pregnant within the next six months;

Positive virology tests for hepatitis B, hepatitis C, HIV, syphilis, or cytomegalovirus;

History of other tumors (except for those with skin or cervical in situ cancers that have been cured by radical treatment and show no evidence of disease activity);

Previously received treatment targeting BCMA;

Trial design

Treatments tested in this trial

  • CAR-T treatment

Treatment groups

5 Participants
are divided into 1 treatment group